CHAPTER 1. LITERATURE REVIEW.
Part 1. Erythema multiforme exudative……………………………………8
1.1 Classification, clinical manifestations…………………………………….8
1.2. Concepts of pathogenesis………………………………………………...10
1.3. Treatment of erythema multiforme exudative……………….………….11
Part 2. Herpes simplex - immunogenesis and therapy
2.1. Immunogenesis………………………………………………………….12
2.2. Herpes simplex therapy…………………………………………………..16
Part 3. Herpes-associated erythema multiforme.
3.1. The etiological role of the herpes simplex virus statistical data and
methods of laboratory verification……………………………………………18
3.2. Modern view on the pathogenesis of GAME…………………………….19
3.3 GAME treatment………………………………………………………….22
CHAPTER 2. MATERIALS AND METHODS.
2.1 Composition of patient groups……………………………………………24
2.2 Medicines and the main regimens for their administration……………….27
CHAPTER 3. RESULTS OF OWN RESEARCH.
Part 1. Clinical observation data.
3.1 Age and sex composition of patients……………………………………..30
3.2. Clinical features of the rashes of herpes simplex, which provoked the
development of GAME……………………………………………………….35
3 .2. Clinical Features of the course of GAME………………………………35
Part 2. Data of Immunological examination…………………………………..41
3.1. Immune status disorders detected in patients with GAME in comparison
with those in PH and other forms of MEE. …………………………………..45
INTERFERONS………………………………………………………………45
Humoral immunity……………………………………………………………48
Phagocytosis System………………………………………………………….51
Immune complex……………………………………………………………...52
Differented approach to game therapy………………………………………..53
3.2. Prevention of GAME…………………………………………………….59
DISCUSSION………………………………………………………………..59
FINDINGS……………………………………………………………………69
PRACTICAL RECOMMENDATIONS…………………….……….……….71
PROVISIONS FOR THE DEFENSE……………………………….………..73
LITERATURE………………………………………………………………..74
