KIRISh……………………………………………………………………...................4-10
IBOB. ADABIYOTLAR ShARXI
1.1. Silliq muskullar hujayralarining tuzilishi to‘g‘risida hozirgi zamon tushunchalari....................................................................................................................11-12
1.2. Silliq muskul hujayralarining funksiyasi.................................................................12-19
1.3. Silliq muskul hujayralari ion transport tizimlari……....................................19-27
1.4.Qon tomir devori silliq muskul hujayralari funksiyasi ta’minlanishining molekulyar mexanizmlari……………………27-30
1.5. Silliq muskul hujayrasi plazmolemmasida joylashgan reseptor va ion–transport tizimlari………………………………………………....................................................30-38
Bob bo‘yicha xulosalar....................................................................................................38-41
II BOB. MATERIAL VA METODLAR
2.1. Tadqiqot ob’yektlari………….................................................................................42-43
2.2. Kalamush aortasi preparatlarini tayyorlash va ularning qisqarish faolligini qayd qilish...............................................................................................................................43-44
2.3. Tajribalar sxemasi..................................................................................................44-46
2.3.1. Giperkaliyli eritmalar yordamida silliq muskul hujayralari qisqarishini yuzaga keltirish............................................................................................................................46-47
2.3.2. Noradrenalin yordamida silliq muskul hujayralari qisqarishini yuzaga keltirish...........................................................47-48
2.4. Olingan natijalarni statistik qayta ishlash...............................................................48-50
Bob bo‘yicha xulosalar.......................................................................................50
III BOB. 1,2,3-TRI-O-GALLOIL--D-GLYUKOZA (PF-1) VA 3-O-GALLOIL-4,6-GEKSAGIDROKSIDIFENOIL--D-GLYUKOZA (PF-2) POLIFENOLLARINING AORTA SILLIQ MUSKULI PLAZMOLEMMASI ION TRANSPORT TIZIMLARIGA TA’SIRI
3.1. PF-1 va PF-2 polifenollarining aorta silliq muskuliga relaksant ta’sirida potensialga bog‘liq Ca2+L–kanali va reseptor orqali boshqariluvchi Ca2+R–kanallarining ro’lini aniqlash................................................................................................................51-59
3.2. PF-1 va PF-2 polifenollarining aorta silliq muskuliga relaksant ta’sirida Na+/Ca2+–almashuvchi tizimning ro’li..........................................................................................59-63
3.3. PF-1 va PF-2 polifenollarining aorta silliq muskuliga relaksant ta’sirida K+ -kanallarining ishtroki.....................................................................................................63-66
Bob bo‘yicha xulosalar...................................................................................................66-67
IV BOB. 1,2,3-TRI-O-GALLOIL--D-GLYuKOZA (PF-1) VA 3-O-GALLOIL-4,6-GEKSAGIDROKSIDIFENOIL--D-GLYuKOZA (PF-2) POLIFENOLLARINING AORTA SILLIQ MUSKULI SARKOPLAZMATIK RETIKULUM Ca2+-TRANSPORT TIZIMLARIGA TA’SIRI
4.1. PF-1 va PF-2 polifenollarining aorta silliq muskulining inozitol–1,4,5–trifosfat reseptorilariga ta’siri.........................................................................................................68-70
4.2. PF-1 va PF-2 polifenollarining aorta silliq muskulining rianodin (RyR) reseptoriga ta’siri......................71-73
4.3. PF-1 va PF-2 polifenollarining aorta silliq muskulining sarkoplazmatik retikulum Ca2+-ATFaza tizimlariga ta’siri.......................................................................................73-75
Bob bo‘yicha xulosalar...................................................................................................75-76
XULOSALAR................................................................................................................77
FOYDALANILGAN ADABIYOTLAR RO‘YXATI..................................................78-93
