KIRISH ..........................................................................................................3-10
I BOB. ADАBIYOTLAR SHARHI
1.1.Qon tomirlar silliq muskul hujayralarining struktura-funksiyasining o’ziga xos hususiyatlari ................................................................................10-16
1.2 Qon tomir silliq muskul hujayralarining qisqarish va bo’shashish mexanizmlari .................................................................................................16-20
1.3. Qon tomir silliq muskullari funksional faolligida ion-transport tizimlarining roli ............................................................................................21-23
1.3.1. Na+-kanali .................................................................................24-25
1.3.2. K++kanallari .............................................................................24-27
1.3.3. L tipidagi Ca2+-kanali................................................................28-34
1.3.4. Na+/Ca2+-almashinuv tizimi......................................................34-41
1.4. Adrenoretseptorlarning qon tomir silliq muskul hujayrasi qisqarish faolligidagi ahamiyati ....................................................................................41-44
1.5. Ayrim geterosiklik birikmalarning kimyoviy va farmokologik hususiyatlari. .................................................................................................44-46
1.6. Triazollarning qon tomir silliq muskul hujayralari funksional faolligiga ta’siri…………………………………………..…………………….46
I-bob bo’yicha hulosa .........................................................................47-49
II BOB. ILMIY TADQIQOT MATERIALLARI USULLARI
2.1. Tadqiqot obyekti va sharoiti ............................................................50
2.2. Aorta qon tomiri preperatining izometrik qisqarish faolligini qayd qilish uslubi (mexanografiya) .......................................................................50-52
2.3. Tajriba protokollari (sxemalari) ..................................................52-54
2.4. Olingan natijalarni statistik qayta ishlash ...................................54-55
II-bob bo’yicha xulosa ............................................................................55
III BOB. OLINGAN NATIJALAR VA ULARNING MUHOKAMASI
3.1. D-115 oksadiazol hamda uning hosilasi D-378 triazolning aorta silliq muskul hujayralari Ca2+L-tip kanallariga dozaga bog’liq relaksant ta’sirini o’rganish.................................................................................................56-62 3.2. D-115 oksadiazol hamda uning hosilasi D-378 triazolning relaksant ta’sirida Na+/Ca2+ almashuvchining o’rnini aniqlash ............................62-66
3.3. D-115 oksadiazol hamda uning hosilasi D-378 triazolning relaksant ta’sirini ta’minlashda SMH laridagi sarkoplazmatik retikulumdagi Ca2+-tashish (IP3R, RyR) tizimlarining o’rnini aniqlash....................................................66-72
III-bob bo’yicha xulosa ............................................................................72
XULOSALAR .........................................................................................73
ADABIYOTLAR RO’YHATI..........................................................74-85
