KIRISH.....................................................................................................................
1 BOB DIABETIK NEFROPATIYA RIVOJLANISHI VA TARQALI-
SHINING 0 ‘ZIGA XOS JIHATLARI................................................................
§1.1. Diabetik nefropatiya tarqalishining epidemiologik j ihatlari...................
§ 1.2. Diabetik nefropatiya rivojlanishining patogenetik mexanizmlari...........
§1.3. Diabetik nefropatiyaning keltirib chiqaruvchi xavf omillarining o‘ziga
xos xususiyatlari.........................................................................................
§ 1.4. Diabetik nefropatiya rivojlanishida genetik omillar................................
§1.5. Diabetik nefropatiya rivojlanishida nomzod genlami o‘ziga xos
jihatlari.........................................................................................................
4
14
14
16
21
30
32
II BOB. KLINIK MATERIALLAR VA TADQIQOT USULLARIGA
UMUMIY TAVSIF.....................................................................................................49
§2.1. Tadqiqotning material va tekshirish usullari................................................49
§2.2. Umumiy laborator-instrumental tekshiruv usullari................................. ....49
§2.3. Molekular-genetik tekshirish usullari....................................................... ...50
§2.4. Statistik tahlil usullari................................................................................ ... 53
III
BOB. DIABETIK NEFROPATIYA BILAN KASALLANGAN
BEMORLARDA KASALLIKNING KLINIK XUSUSIYATLARI VA
DIAGNOSTIK JIHATLARNI TAHLIL QILISH............................................
§3.1. Diabetik nefropatiya bilan kasallangan normaalbuminuriya va
mikroalbuminuriya bosqichidagi bemorlar guruhlarida kliniko
bioximik va instrumental ko‘rsatkichlami tahlil qilish...........................
§3.2. Diabetik nefropatiya bilan kasallangan normaalbuminuriya va
mikroalbuminuriya bosqichidagi bemorlar guruhlarida buyraklaming
funksional holatini baholash......................................................................
§3.3. Diabetik nefropatiya bilan kasallangan normaalbuminuriya va
55
55
56
2
mikroalbuminuriya bosqichidagi bemorlar guruhlarida buyrak ichi
gemodinamikasi ko‘rsatkichlari................................................................
§3.4. Diabetik nefropatiya bilan kasallangan normaalbuminuriya va
mikroalbuminuriya
bosqichidagi
bemorlar
guruhlarida
chap
qorinchaning remodellashishi ko‘rsatkichlari..........................................
IV BOB. DIABETIK NEFROPATIYA RIVOJLANGAN BEMORLARDA
GENETIK TEKSHIRUV NATIJALARI............................................................
§4.1. Diabetik nefropatiya bilan kasallangan normaalbuminuriya va
mikroalbuminuriya bosqichidagi bemorlar guruhlarida AGTR1
genining A1166C polimorf markerining o‘mi.........................................
§4.2. Diabetik nefropatiya bilan kasallangan normaalbuminuriya va
mikroalbuminuriya bosqichidagi bemorlar guruhlarida MTHFR
genining C677-T polimorfizmining axamiyati.........................................
V BOB. GENOTIPIK VA FENOTIPIK BELGILARNING 0 ‘ZAR0
TA’SIRINI 0 ‘RGANISH.......................................................................................
XOTIMA..................................................................................................................
XULOSA...................................................................................................................
AMALIY TAVSIYALAR......................................................................................
FOYDALANILGAN ADABIYOTLAR..............................................................
60
62
65
65
70
76
79
92
94
95
SHARTLIBELGILAR VA ATAMALAR RO‘YXATI.................................... 114
